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More Information and Recent Research on Stroke

(MedPage Today) The amount of dental care and periodontal disease was significantly correlated to incident stroke (IR) risk, a nationwide, population-based study found.
(Science Daily) Depressed middle-aged women have almost double the risk of having a stroke, according to research… "When treating women, doctors need to recognize the serious nature of poor mental health and what effects it can have in the long term," said Caroline Jackson, Ph.D., study author… "Current guidelines for stroke prevention tend to overlook the potential role of depression."
(Science Daily) People who have a traumatic brain injury (TBI) may be more likely to have a future stroke, according to research… After adjusting for factors that can affect stroke risk, such as age, high blood pressure and high cholesterol, as well as other disorders such as heart disease and the severity of the trauma, the researchers found that people with traumatic brain injury were 30 percent more likely to develop a stroke than those with trauma with no brain injury.
(MedPage Today) Damage to the retina from hypertension independently pointed to elevated stroke risk, even when blood pressure was controlled by medication, an observational study showed… Among individuals with blood pressure well-controlled on antihypertensives, even mild retinopathy predicted double the cerebral infarct risk of those without any retinopathy, the researchers reported.
(European Society of Cardiology) General practitioners (GPs) undertreat women with atrial fibrillation (AF), according to research… The analysis of more than 15,000 patients showed that women were undertreated with antithrombotic medications compared to men regardless of their stroke risk and comorbidities.
(Science Daily) Patients with five or more risk factors have the same stroke risk as patients with atrial fibrillation, according to research… Dr Benn Christiansen said: "…Our findings suggest that patients without atrial fibrillation or prior stroke may have a stroke risk that is comparable to patients with atrial fibrillation if they have three or more risk factors [such as diabetes, hypertension, myocardial infarction, heart failure and age above 75 years]."
More . . .
Mass Screening Identifies Untreated Atrial Fibrillation in 5% of 75-76 Year Olds
(Science Daily) Mass screening in more than 25,000 Swedish residents has identified untreated atrial fibrillation in 5 percent of 75-76 year olds, putting them at increased stroke risk… Patients with atrial fibrillation have a five-fold increased risk of ischaemic stroke even though around 30% have no symptoms. As blood is less adequately shifted from the heart during atrial fibrillation, blood clots can form and cause large ischaemic strokes.
(American College of Emergency Physicians) Emergency physicians correctly identified nearly 100 percent of patients with Bell's palsy, the symptoms of which are nearly identical to potentially life-threatening diseases such as stroke and brain tumors… [S]aid lead study author Jahan Fahimi, MD, MPH… " The combination of thorough history-taking and detailed physical exam allows emergency physicians to determine which patients have a dangerous condition and which can safely be discharged home. While there may be a role for imaging, such as CT or MRI, the overwhelming majority of patients can be evaluated without advanced diagnostic tests."
(MedPage Today) Hospitals participating in a national quality improvement program provided better outcomes for patients with acute ischemic stroke, researchers found.
(MedPage Today) Stroke patients eligible for thrombolytic therapy have significantly better odds of receiving the therapy than they did a few years ago, according to a review of more than a million stroke cases… Thrombolytic therapy with tPA has the highest level of supporting evidence for use in acute ischemic strokes. Despite efforts to increase awareness of stroke and to expand access to acute stroke care, many patients who arrive at the hospital within 3 hours of stroke and have no contraindications to tPA do not receive the therapy, the authors noted.
(MedPage Today) Stroke patients continued to benefit from thrombolytic therapy for at least a year and a half after treatment, long-term follow-up from a randomized trial showed. Patients who received alteplase (Activase) within 6 hours of symptom onset had a significantly more favorable functional profile at 18 months compared with placebo.
(Science Daily) The combination of the clot-busting drug tPA with an infusion of the antiplatelet drug eptifibatide dissolves blood clots safely and more quickly than tPA alone, a study led by University of Cincinnati (UC) researchers has found.
(Science Daily) In the latest in a series of experiments testing the use of stem cells to treat neurological disease, researchers at Henry Ford Hospital have shown for the first time that microscopic material in the cells offers a "robust" treatment for crippling stroke… The research team found that after inducing stroke in lab rats, injecting exosomes containing [RNA] into their blood prompted remodeling of the affected brain, including increased production of new brain cells, blood vessels and neural rewiring. Together, these effects significantly improved neurological function that had been impaired by stroke.
(Science Daily) A new study finds that stroke patients' brains show strong cortical motor activity when observing others performing physical tasks -- a finding that offers new insight into stroke rehabilitation… Activating regions near the damaged portion of the brain is like exercising it, building strength that can help it recover to a degree.
(Forbes) Ampyra, a pill approved to help patients with multiple sclerosis walk, … may also help patients who can’t walk because of a stroke… When patients were taking Ampyra, they were able to do better on a test that timed how long it took them to walk 25 feet. The difference was statistically significant.
(Science Daily) The world's first Brain Training Device has given a ray of new hope to the recovery of survivors after stroke. Developed by researchers of The Hong Kong Polytechnic University, this novel device can detect brainwave and control the movement of paralyzed limbs.
(Science Daily) A new study details of a technique developed by researchers to improve language function in stroke patients with chronic speech-language impairment… Initial results from work with a well curated population of stroke patients in Dr. Hamilton's laboratory demonstrate long-term improvement in language production after [transcranial magnetic stimulation (TMS)] stimulation.
(USA Today) A stroke may leave some survivors with post-traumatic stress disorder, which may hinder their recovery, according to a study… About 23% of patients who survive a stroke or transient ischemic attack, a brief interruption of blood flow to the brain, have PTSD symptoms within a year, the study finds. About 11% have chronic PTSD, in which symptoms last three months or longer, more than a year later… "Strokes are among the most terrifying life-threatening events," says lead author Donald Edmondson.
(MedPage Today) Roughly one in every 10 patients who suffer an ischemic stroke will develop a new chronic pain syndrome, which might increase the risk of cognitive and functional decline, researchers found.
(Science Daily) Results of a Phase III clinical trial showed that a simple drug regimen of two anti-clotting drugs -- clopidogrel and aspirin -- lowered the risk of stroke by almost one-third, compared to the standard therapy of aspirin alone, when given to patients who had minor or transient stroke symptoms to prevent subsequent attacks.
(MedPage Today) The three newest anticoagulants -- dabigatran (Pradaxa), apixaban (Eliquis), and rivaroxaban (Xarelto) -- are cost-effective relative to warfarin for preventing stroke in patients with nonvalvular atrial fibrillation, researchers found.
(Science Daily) One of regenerative medicine's greatest goals is to develop new treatments for stroke. So far, stem cell research for the disease has focused on developing therapeutic neurons -- the primary movers of electrical impulses in the brain -- to repair tissue damaged when oxygen to the brain is limited by a blood clot or break in a vessel. New UC Davis research, however, shows that other cells may be better suited for the task… [The] study found that astrocytes -- neural cells that transport key nutrients and form the blood-brain barrier -- can protect brain tissue and reduce disability due to stroke and other ischemic brain disorders.
(Henry Ford Health System) A study by researchers at Henry Ford Hospital found "substantial evidence" that a regenerative process involving damaged nerve fibers in the spinal cord could hold the key to better functional recovery by most stroke victims.
Community: There are many practical things we can do to prevent, delay, or minimize the severity of stroke.


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