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More Recent News and Research on Diabetes

(BBC News) Keeping your kidneys healthy could be one of the best ways to extend your life if you have Type 2 diabetes, researchers have suggested. The University of Washington study found that having kidney disease meant a much higher risk of early death.
(Bloomberg) The number of Americans with vision loss not correctable by glasses is rising, caused in part by increasing diabetes rates, a study found… About 2.15 million people in the U.S. ages 20 and older suffer from non-refractive visual impairment, which can take surgery or lasers to repair, said David Friedman, a study author. Based on [the] findings, more effort is needed to prevent diabetes and ensure that those who have the disease get yearly eye exams, he said.
(Science Daily) A new therapeutic approach to diabetes that combines insulin and an inhibitor of the epidermal growth factor (EGF) betacellulin could limit the progression of diabetic macular edema (DME), Cleveland Clinic researcher Bela Anand-Apte, MD, PhD, said… The study, conducted with insulin-dependent diabetic mice, showed that by thwarting "cross-talk" between insulin and betacellulin (BTC), which promotes the regeneration of pancreatic beta cells that stores and releases insulin, the EGF inhibitor preserved the animals' vascular integrity, she explained.
(Science Daily) For some people with diabetes, there may be such a thing as too much care. Traditional treatment to reduce risks of heart disease among patients with diabetes has focused on lowering all patients' blood cholesterol to a specific, standard level. But this practice may prompt the over-use of high-dose medications for patients who don't need them, according to new research.
(WebMD Health News) An FDA advisory panel has given its blessing to canagliflozin (Invokana) for the treatment of type 2 diabetes… Taken by mouth once a day, the drug could be the first in a new class of diabetes drugs called sodium-glucose cotransporter 2 (SGLT2) inhibitors. Canagliflozin works to reduce the amount of blood sugar (glucose) reabsorbed by the kidneys. This results in glucose being expelled in the urine. Preliminary data suggest that people who take the new medication have lower glucose levels and also lose weight.
More . . .
(University of Texas Medical Branch at Galveston) [R]esearchers have discovered that the commonly used antidepressant drug paroxetine could also become a therapy for the vascular complications of diabetes. The scientists made their discovery after screening 6,766 clinically used drugs and pharmacologically active substances… [S]aid UTMB professor Csaba Szabo, … "We were quite surprised when paroxetine came out as an active compound —a result, we later determined, of what seems to be a completely new effect unrelated to its antidepressant actions and not shared by any other known antidepressant drug."
(Walter and Eliza Hall Institute) For the first time, researchers have captured the intricate way in which insulin uses the insulin receptor to bind to the surface of cells. This binding is necessary for the cells to take up sugar from the blood as energy… [Said Associate Professor Mike Lawrence,] "This discovery could conceivably lead to new types of insulin that could be given in ways other than injection, or an insulin that has improved properties or longer activity so that it doesn't need to be taken as often. It may also have ramifications for diabetes treatment in developing nations, by creating insulin that is more stable and less likely to degrade when not kept cold, an angle being pursued by our collaborators. Our findings are a new platform for developing these kinds of medications."
(Science Daily) Scientists observed that blocking the expression of the gene TRIP-Br2 in mice protects them against obesity and insulin resistance. The study shows that the gene modulates fat storage by regulating energy expenditure and lipolysis, the process which transforms fat into lipids for the body's energy consumption. If the gene expression is blocked, the mice increase their lipolysis and their energy expenditure, thus reducing their obesity.
(Science Daily) A team … found that the diabetes drug metformin works in a different way than previously understood. Their research in mice found that metformin suppresses the liver hormone glucagon's ability to generate an important signaling molecule, pointing to new drug targets.
(Reuters Health) Diabetic patients too often walk without wearing their custom-made shoes designed to prevent foot sores that can lead to infections and amputations, new research finds. "It's very important that patients wear prescribed footwear as much as possible," said senior author, Sicco Bus… "High-risk patients are too low in their adherence, and that needs to be improved."
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