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Doubt Cast on Use of Genetic Test Before Plavix

(HealthDay News) A new review of existing research suggests that, despite a federal recommendation, genetic testing won't help physicians determine which heart patients should get Plavix, a blood-thinning drug used to treat certain cardiac conditions…
The U.S. Food and Drug Administration believes that genetic testing could help identify patients who won't respond well to the drug. But the American Heart Association and the American College of Cardiologists have been skeptical that the genetic testing in question is useful…
[Dr. Steven E. Nissen], chair of cardiovascular medicine at the Cleveland Clinic, noted that the review has limitations. But, he added, for the time being physicians should "rarely, if ever" use the genetic testing in question and should "interpret the results with caution."
[Dr. Jean-Sebastien Hulot at Mount Sinai School of Medicine] is skeptical. He said the findings are "far from convincing" and questioned their statistical validity. He also pointed to an earlier study, also a meta-analysis, that suggested a genetic trait did indeed boost the risk of problems for those who took the drug in certain cases.
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