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Blood pressure hormone promotes obesity

(University of Iowa Health Care) The renin-angiotensin system (RAS) controls blood pressure and is important for cardiovascular health. Many of the drugs used to treat hypertension (high blood pressure) and heart failure block or inhibit the RAS…
When the RAS is elevated in the brain, it increases energy expenditure by increasing resting metabolism, resulting in weight loss. However, increased activity of the RAS circulating in the body (the peripheral RAS) -- which occurs during obesity in humans and experimental animals -- has the opposite effect, decreasing resting metabolism and increasing weight gain…
A more precise understanding of how the RAS acts in tissue-specific and receptor-specific ways to influence energy balance may ultimately be useful for developing new ways to treat obesity and the health problems associated with it.
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